The Casa de Colon (Columbus's House) is situated in the old quarter of Vegueta and is a fine example of Colonial architecture. It houses a valuable collection of objects and documents dating from the 15th century as well as an impressive model of Columbus's route to the Americas. The museum offers an excellent and educational visit.

The Canarian Museum is also located in the same old quarter and is based on the people who have inhabited the island over the centuries. Here you can see the customs and religions traditional to the island before the Spanish arrived. There are also mummies on display, prepared using the same method as the Egyptians used. The library also contains more than 50,000 books and newspapers.

The Museum of Perez Galdos contains the writer's complete works as well as important letters and manuscripts.

The Nector Museum is located inside the cathedral and contains the island's best treasures including important art from the 15th-18th centuries. The cathedral itself took 73 years to build and is still incomplete in parts. Tourists come here on Thursdays and Sundays to see exhibitions of Canarian dance and music.